Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9977 |
SGK1-IN-4
|
SGK | Metabolism |
SGK1-IN-4 是 SGK1 的特异性抑制剂,可用于骨关节炎研究。 | |||
T6635 |
EMD638683
|
SGK | Metabolism |
EMD638683 是一种具有抗高血压效力的新型 SGK 抑制剂,IC50=3 μM。 | |||
T2622 |
GSK 650394
GSK650394 |
SGK; Influenza Virus | Metabolism; Microbiology/Virology |
GSK 650394 是一种新颖的 SGK 抑制剂,可抑制流感病毒复制。它还是一种血清和糖皮质激素调节的激酶 1 抑制剂。 | |||
T19913 |
CKI-7
CKI 7 2HCl,CKI-7 dihydrochloride,N-(2-氨基乙基)-5-氯异喹啉-8-磺酰胺二盐酸盐,CKI7 2HCl,CKI 7 dihydrochloride,CKI7 dihydrochloride,CKI-7 2HCl |
ROCK; SGK; Casein Kinase; CDK; S6 Kinase | Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells |
CKI-7 是一种有效且 ATP 竞争性的酪蛋白激酶 1 抑制剂,IC50为 6 μM,Ki 为 8.5 μM。它选择性抑制 Cdc7激酶,还抑制 SGK,S6K1以及 MSK1。 | |||
T12891 | SGK1-IN-2 | Others | Others |
SGK1-IN-2 (14h) is a selective inhibitor of SGK1 (serum and glucocorticoid regulated kinase 1)(with an IC50 of 5 nM at 10 μM ATP concentration). | |||
T71947 |
SGK1 inhibitor
|
||
SGK1 inhibitor is an inhibitor of serum- and glucocorticoid-regulated kinase 1 (SGK1) and SGK2. It is selective for SGK1 and SGK2 over SGK3 in the presence of a high concentration of ATP. SGK1 inhibitor prevents phosphorylation of GSK3β in U2OS cells and decreases cell viability in BYL719-insensitive HCC1954 cells when used in combination with the PI3Kα inhibitor BYL719. SGK1 inhibitor reduces tumor growth in an HCC1954 mouse xenograft model when administered in combination with BYL719. |